Deal Flurry Shows Drug Makers' Swing Toward Specialization

Wall Street Journal : April 23, 2014
After decades of broadening their drug portfolios through acquisitions, pharmaceutical companies are reversing course to focus more narrowly on what they think they can do best.

Well: The Limits of ‘No Pain, No Gain’

New York Times - Health : April 23, 2014
A new study helps to explain why exercise makes our muscles ache, and suggests that it’s not always a good idea to ignore fatigue and push on.

Michigan man among 1st in US to get 'bionic eye'

Associated Press Healthwire : April 23, 2014
ANN ARBOR, Mich. (AP) -- A degenerative eye disease slowly robbed Roger Pontz of his vision....

Violent crime 'continues to fall'

BBC Health : April 23, 2014
Violent crime is continuing a long-term fall in England and Wales, according to annual figures from NHS hospitals.

Clwyd hospital care claims rejected

BBC Health : April 23, 2014
Serious complaints made by a Labour MP over the hospital care given to her husband before his death are rejected following an independent investigation.

Trust 'failed' on 111 call answering

BBC Health : April 23, 2014
The South Western Ambulance Service chief executive says the service has "failed to deliver the performance required" in answering weekend calls to the NHS 111 number.

For an immune cell, microgravity mimics aging

ScienceDaily: Health & Medicine : April 22, 2014
Telling someone to "act your age" is another way of asking him or her to behave better. Age, however, does not always bring improvements. Certain cells of the immune system tend to misbehave with age, leaving the elderly more vulnerable to illness. Because these cells are known to misbehave similarly during spaceflight, researchers are studying the effects of microgravity on immune cells to better understand how our immune systems change as we age.

Splashy plan for pool in NYC's East River unveiled

Associated Press Healthwire : April 22, 2014
NEW YORK (AP) -- Forget Jones Beach or the Jersey Shore. A design team says New York's East River could soon be the place for summer fun....

Orangetheory fitness?

CNN Health : April 22, 2014
A relatively new workout program revolves around participants' heart rates. Holly Firfer explains Orangetheory fitness.

Applying math to biology: Software identifies disease-causing mutations in undiagnosed illnesses

ScienceDaily: Health & Medicine : April 22, 2014
A computational tool has successfully identified diseases with unknown gene mutations in three separate cases. Sequencing the genomes of individuals or small families often produces false predictions of mutations that cause diseases. But this study shows that a new unique approach allows it to identify disease-causing genes more precisely than other computational tools.

Fat metabolism in animals altered to prevent most common type of heart disease

ScienceDaily: Health & Medicine : April 22, 2014
Working with mice and rabbits, scientists have found a way to block abnormal cholesterol production, transport and breakdown, successfully preventing the development of atherosclerosis, the main cause of heart attacks and strokes and the number-one cause of death among humans. The condition develops when fat builds inside blood vessels over time and renders them stiff, narrowed and hardened, greatly reducing their ability to feed oxygen-rich blood to the heart muscle and the brain.

Glaxo Exits Cancer Drugs

Wall Street Journal : April 22, 2014
GlaxoSmithKline's decision to leave the hot field of cancer drugs narrows the focus of its business to just four areas: respiratory and HIV treatments, vaccines and consumer-health products.

Management of elderly patients with lung cancer

ScienceDaily: Health & Medicine : April 22, 2014
An expert opinion on managing treatment for elderly patients with non-small cell lung cancer has been recently published. This update includes recommendations for screening, surgery, adjuvant chemotherapy and radiotherapy, treatment of locally advanced and metastatic disease as well as new data on patient preferences and geriatric assessment.

Male health linked to testosterone exposure in womb, study finds

ScienceDaily: Health & Medicine : April 22, 2014
Men's susceptibility to serious health conditions may be influenced by low exposure to testosterone in the womb, new research suggests. Understanding why some men have less of the hormone than others is important because testosterone is crucial for life-long health. Low levels of the hormone have been linked to obesity, diabetes and heart disease.

Life stressors trigger neurological disorders, researchers find

ScienceDaily: Health & Medicine : April 22, 2014
When mothers are exposed to trauma, illness, alcohol or other drug abuse, these stressors may activate a single molecular trigger in brain cells that can go awry and activate conditions such as schizophrenia, post-traumatic stress disorder and some forms of autism. Until now, it has been unclear how much these stressors have impacted the cells of a developing brain. Past studies have shown that when an expectant mother exposes herself to alcohol or drug abuse or she experiences some trauma or illness, her baby may later develop a psychiatric disorder later in life. But the new findings identify a molecular

Turoctocog alfa in patients with hemophilia A: Added benefit not proven

ScienceDaily: Health & Medicine : April 22, 2014
As no relevant studies and no valid data are available, the added benefit of turoctocog alfa over other blood-clotting agents is not proven, a publication concludes. Turoctocog alfa (trade name: NovoEight) has been approved since November 2013 for the prevention and treatment of bleeding in patients with hemophilia A.

Researchers identify a new variant of Ebola virus in Guinea

ScienceDaily: Health & Medicine : April 22, 2014
In a new article, researchers have published their initial findings on the characteristics of the Ebola virus discovered in Guinea. Initial virological investigations enabled them to identify Zaire ebolavirus as the pathogen responsible for this epidemic.

End-of-life directives added into EHR

Healthcare IT News : April 22, 2014
UMass Memorial Health Care is partnering with Minneapolis-based Lumināt, which develops care planning tools, to create a platform that will integrate patients' end-of-life directives into their electronic health records. [See also: NQF supports 12 new end-of-life quality measures] read more

Healthcare security stuck in Stone Age

Healthcare IT News : April 22, 2014
Healthcare has a few things to do differently in the privacy and security arena -- one of them being: Start taking it seriously. This according to Verizon's annual breach report released today.   The new 2014 Verizon Data Breach Investigations Report highlights a concerning carelessness regarding privacy and security, specific to the healthcare industry.    read more

ACO success key to value-based care

Healthcare IT News : April 22, 2014
If the U.S. is going to get a handle on healthcare spending, then providers and healthcare organizations are going to have to get serious about accountable care organizations, says one expert. read more

Athenahealth quits EHR association

Healthcare IT News : April 22, 2014
Cloud-based EHR company athenahealth will resign from the EHR Association. Its executives say it does not belong there, since it is neither an EHR company nor a software vendor. In a news release announcing its resignation from the EHR Association, athenahealth executives said: read more

How often are unauthorized immigrant workers trafficked, abused?

ScienceDaily: Health & Medicine : April 22, 2014
Labor trafficking -- or recruiting a person for labor through force, fraud, or coercion for involuntary servitude, debt bondage, or even slavery –- has been a difficult problem to track among undocumented migrant workers. With unique access to a 'hidden population' from one of America's largest Spanish-speaking immigrant destinations, a recent study finds that more than 30 percent of undocumented migrant laborers in this area are victims of labor trafficking and 55 percent are victims of other labor abuses.

DealBook: Seeking the Right Chemistry, Drug Makers Hunt for Mergers

New York Times - Health : April 22, 2014
The offer for Allergan by William A. Ackman and Valeant Pharmaceuticals marks an unusual pairing of activist investor and corporate buyer that could reshape the deal landscape.

Two genes linked to inflammatory bowel disease

ScienceDaily: Health & Medicine : April 22, 2014
Scientists have done what is believed to be the first direct genetic study to document the important function for the Ron receptor, a cell surface protein often found in certain cancers, and its genetic growth factor, responsible for stimulating cell growth, in the development and progression of inflammatory bowel disease.

Child's autism risk accelerates with mother's age over 30

ScienceDaily: Health & Medicine : April 22, 2014
Older parents are more likely to have a child who develops an autism spectrum disorder than are younger parents. A recent study provides more insight into how the risk associated with parental age varies between mothers' and fathers' ages, and found that the risk of having a child with both autism spectrum disorder and intellectual disability is larger for older parents.

Cloaked DNA nanodevices survive pilot mission

ScienceDaily: Health & Medicine : April 22, 2014
By mimicking a viral strategy, scientists have created the first cloaked DNA nanodevice that survives the body's immune defenses. Their success opens the door to smart DNA nanorobots that use logic to spot cancerous tissue and manufacture drugs on the spot to cripple it, as well as artificial microscopic containers called protocells that detect pathogens in food or toxic chemicals in drinking water.

Drug-related morbidity in more than 10 percent of adults, Swedish study finds

ScienceDaily: Health & Medicine : April 22, 2014
Twelve percent of adults in Sweden have diseases related to their use of medicines. But in four cases of ten it would have been possible to avoid the undesired effects, research shows. Two effects were most commonly reported: side effects, and insufficient effect of the drug. "The studies show that both those treating outpatients and those treating inpatients must become better at recognizing drug-related morbidity. Further, new studies should be carried out by scientists, experts in safety and healthcare personnel together to develop preventative strategies," says the researcher.

Bariatric surgery health benefits: Is it bile acids at work?

ScienceDaily: Health & Medicine : April 22, 2014
Bariatric surgery has positive effects not only on weight loss but also on diabetes and heart disease. Researchers have shown that the health benefits are not caused by a reduction in the stomach size but by increased levels of bile acids in the blood. These findings indicate that bile acids could be a new target for treating obesity and diabetes.

FDA proposes new expedited access program for medical devices that address unmet medical needs

FDA US Food & Drug : April 22, 2014
Today, the U.S. Food and Drug Administration proposed a new program to provide earlier access to high-risk medical devices that are intended to treat or diagnose patients with serious conditions whose medical needs are unmet by current technology.

World Briefing: Ebola Outbreak in West Africa Kills Over 140, U.N. Agency Says

New York Times - Health : April 22, 2014
The World Health Organization said on Tuesday that at least 230 suspected or confirmed cases of Ebola had been recorded in Guinea and Liberia.

Gilead Revenue Soars on Hepatitis C Drug

New York Times - Health : April 22, 2014
Gilead Sciences reported $2.3 billion in sales of Sovaldi, a new hepatitis C drug that has raised an outcry over its $1,000-a-pill price.

MRSA at Home

NIH Medline Plus : April 22, 2014
Source: HealthDay - Related MedlinePlus Pages: Infection Control, MRSA

Valeant: A Drug Maker With Little Patience for Science

Wall Street Journal : April 22, 2014
Allergan spends 17% of its revenue on R&D. Michael Pearson has cut Valeant's spending to 3%, setting up a culture clash as he attempts to purchase the Botox maker.

New way to enhance nerve growth following injury discovered

ScienceDaily: Health & Medicine : April 22, 2014
A mechanism to promote growth in damaged nerve cells as a means to restore connections after injury has been uncovered by scientists who have discovered a key molecule that directly regulates nerve cell growth in the damaged nervous system. "We made the surprising discovery that a protein called Retinoblastoma (Rb) is present in adult neurons," explains the lead researcher. "This protein appears to normally act as a brake -- preventing nerve growth."

First brain images of African infants enable research into cognitive effects of nutrition

ScienceDaily: Health & Medicine : April 22, 2014
Brain activity of babies in developing countries could be monitored from birth to reveal the first signs of cognitive dysfunction, researchers say. The cognitive function of infants can be visualized and tracked more quickly, more accurately and more cheaply using the method, called functional near infra-red spectroscopy (fNIRS), compared to the behavioral assessments Western regions have relied upon for decades.

How are we different and what gave us the advantage over extinct types of humans like the Neanderthals?

ScienceDaily: Health & Medicine : April 22, 2014
In parallel with modern man (Homo sapiens), there were other, extinct types of humans with whom we lived side by side, such as Neanderthals and the recently discovered  Denisovans of Siberia. Yet only Homo sapiens survived. What was it in our genetic makeup that gave us the advantage?

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